Mugil cephalus Genome: A Sensitive Monitor for Genotoxicity and Cytotoxicity in Aquatic Environment
نویسنده
چکیده
The precise detection of genotoxic effects induced by environmental contaminants is an essential part of any genetic toxicology screening programme. Fish, however, provides a sensitive monitor for environmental genotoxicity in aquatic environment. Mugil cephalus genome has now been employed in this study for detection of clastogenic and cellular lesions induced by aquatic contaminants in Abu-Qir Bay. Assessment of biological marker at chromosome level in fish, micronucleus test, binucleate as well as the study of abnormal shape of nucleus is a suitable measure, in which the presence or absence of genotoxins can be detected in water. In this study, chromosomal aberrations (CAs), micronuclei (MN), nuclear buds (NB), binucleate cells (BN), and fragmentedapoptotic cells (FA) were analyzed in blood, kidney and gill cells of flathead mullet (Mugil cephalus) which were collected from four different locations along Abu-Qir Bay (hot spot). The data obtained revealed that the tested locations display differential environmental stresses. The location no. 4, ElTabia pumping station, was proven to be highly polluted, since all tested types of alterations were observed. The genotoxic bioassays employed in this work showed that Mugil Cephalus genome is a sensitive biomonitor for genotoxic as well as cytotoxic damage induced by aquatic contaminants. However, differential environmental stresses detected by other researchers in Abu-Qir Bay area are confirmed by the results obtained from this work.
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